How to choose the best ampoules for your filling line

Form C ampoules: Legacy and functionality

Form C ampoules, one of the oldest types, feature a wider opening designed for compatibility with less precise filling needles. They are the preferred choice in North and Central America and parts of Asia and South America. Despite their larger dimensions than Form B, these ampoules offer a practical solution for older fill-and-finish machines. A wider opening is beneficial to avoid droplets of solution into the inner walls of the steam.

Form C ampoules distinguish themselves for having a wider opening (roughly +10%) and greater total height (roughly +10%) than form B.

Form D ampoules: Simplicity since the beginning

Form D ampoules, also known as closed ampoules, were designed for machines without the washing, drying,  and depyrogenation module. At the time they were created, particles were not an issue, and more important was to ease the production for fill-and-finish. With the help of a burner, the CDMO or Pharmaceutical company achieves the opening of the ampoule before filling and the final closing. These ampoules continue being popular in markets such as South America and North and Central America.

The opening and total height dimensions of D ampoules are bigger than in form B and C.

Due to the absence of washing before filling, Form D ampoules pose an elevated risk of potential contamination coming into contact with the drug solution, that can cause a potential threat to patient health. Consequently, it is advisable to recommend Form D ampoules in situations where there is the option of implementing a complete line equipped with a washing and depyrogenation module. This setup enables the use of Form D ampoules, mitigating the risk associated with potential contamination.

Key considerations when navigating ampoule selection

Selecting the best ampoules for your fill-and-finish line involves an in-depth understanding of the different ampoule forms and their compatibility with your manufacturing process. However, choosing the right ampoule involves considerations beyond the fill-and-finish line requirements. Factors such as light sensitivity, and the risk of extractables and leachables should all be considered. 

SCHOTT Pharma offers you a broad portfolio which includes FIOLAX® CHR Borosilicate Glass for high sensible solutions (and/or an improved conversion process to achieve higher hydrolytic resistance levels) and different break-systems, between them, eaysOPC whose breakforce range and consistency eliminates hard to open ampoule, while protecting HCPs from injuries while opening these glass containers.

SCHOTT Pharma: Pioneering ampoule technologies

SCHOTT Pharma, a leading provider of pharmaceutical packaging solutions, offers an extensive range of ampoules designed to meet diverse fill-and-finish needs. More than 100 years of expertise in producing ampoules, allows us to adapt to all our customers’ needs, simplifying your fill-and-finish processes while decreasing your total cost of ownership. 

If you would like to learn more about our drug container solutions, please get in touch by filling out the contact form below.