EVERICĀ® lyo Pharmaceutical vial designed for fogging prevention during lyophilization
Prevent fogging and improve residual emptying
Due to low stability in liquid form, over 50% of biologics are lyophilized. But fogging during freeze-drying can lead to costly rejects. In addition, vials are often overfilled to offset losses from poor residual emptying after reconstitution.
To address these challenges, EVERICĀ® lyo features a hydrophobic surface. This is achieved through plasma impulse chemical vapor deposition (PICVD), which forms a covalently bonded inner coating that avoids the need for siliconization, which can increase the risk of free silicone. This innovative design prevents fogging during lyophilization and improves residual emptying after reconstitution.
Made of Type I Borosilicate Glass and available in TopLine quality, these pharmaceutical glass vials offer improved lyophilization for injectable drugs thanks to their chemically uniform hydrophobic inner coating.
Ultimately, EVERICĀ® lyo not only minimizes fogging and improves residual emptying but also enhances patient safety and lyophilization efficiency.
A unique combination of hydrophobic behavior and no free silicone
EVERICĀ® lyo is unique because of its hydrophobic inner surface, formed without the use of silicone. This is particularly beneficial since the risk of free silicone is reduced. Made of high quality Type I FIOLAXĀ® Borosilicate Glass, EVERICĀ® lyo vials prevent fogging during lyophilization and offer less risk of lyo cake disruption, resulting in fewer cosmetic rejects and reduced production costs.
Improved lyophilization process for injectable drugs
EVERICĀ® lyo vials are designed to prevent fogging and improve residual emptying, ensuring patient safety and dosing accuracy. With vaccines often mass-produced and requiring stable storage for transport, EVERICĀ® lyo pharmaceutical glass vials support a seamless fill-and-finish process. Their hydrophobic inner coating reduces fogging during freeze-drying, addressing challenges that are typical for sensitive formulations such as antibody-drug conjugates (ADCs), as well as a variety of other drugs.
In addition, its compatibility with EVERICĀ® amber makes EVERICĀ® lyo and amber the perfect fit for light-sensitive ADCs, ensuring light transmission compliance with the USP, Ph. Eur. and JP regulatory bodies.
Available in pre-washed, pre-sterilized ready-to-use (RTU) configurations, they are compatible with a wide range of fill-and-finish lines and can remain nested throughout the whole process, including freeze-drying.
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Product Name |
Product Name
EVERICĀ® lyo
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Product Name
EVERICĀ® pure
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Product Name
EVERICĀ® care
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Product Name
EVERICĀ® freeze
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Product Name
EVERIC® strong & smooth
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Product Name
EVERICĀ® smart
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Product Name
EVERICĀ® plus
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Product Name
adaptiQĀ®
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Product Name
Core Vials
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Applications |
Applications
Drugs that need lyophilization
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Applications
Default solution for biologics, diluents, low-filled and high-value drugs
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Applications
Drugs in high alkaline pH range
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Applications
Drugs that need deep-cold storage down to -80°
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Applications
Improved bulk fill-and-finish
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Applications
Track and trace solution
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Applications
Leachable-sensitive drugs in neutral and acidic pH range
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Applications
Pre-washed and pre-sterilized for leaner fill-and-finish
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Applications
Default solution for generics, chemicals
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Tubing Container Material |
Tubing Container Material
FIOLAXĀ®
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Tubing Container Material
FIOLAXĀ® CHR (controlled hydrolytic resistance)
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Tubing Container Material
FIOLAXĀ® CHR (controlled hydrolytic resistance)
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Tubing Container Material
FIOLAXĀ® OS (optimized strength)
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Tubing Container Material
FIOLAXĀ® OS (optimized strength)
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Tubing Container Material
FIOLAXĀ®
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Tubing Container Material
FIOLAXĀ®
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Tubing Container Material
Depending on bulk vial used
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Tubing Container Material
FIOLAXĀ®
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Format |
Format
2-50R
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Format
2-50R
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Format
2R, 6R, 10R
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Format
2-30R
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Format
2-30R
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Format
2-30R
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Format
2-50R
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Format
2-50R
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Format
2-100R
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Quality Level |
Quality Level
TopLine
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Quality Level
TopLine
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Quality Level
TopLine
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Quality Level
TopLine
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Quality Level
TopLine
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Quality Level
TopLine
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Quality Level
TopLine
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Quality Level
TopLine
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Quality Level
StandardLine, TopLine, TopLine Packages
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Closure Systems |
Closure Systems
Stopper + seal
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Closure Systems
Stopper + seal
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Closure Systems
Stopper + seal
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Closure Systems
Stopper + seal
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Closure Systems
Stopper + seal
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Closure Systems
Stopper + seal
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Closure Systems
Stopper + seal
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Closure Systems
Stopper + seal or press-fit cap
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Closure Systems
Stopper + seal
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Pre-washed Pre-sterilized |
Pre-washed Pre-sterilized
Non-sterile and sterile (adaptiQĀ®) available
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Pre-washed Pre-sterilized
Non-sterile and sterile (adaptiQĀ®) available
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Pre-washed Pre-sterilized
Non-sterile and sterile (adaptiQĀ®) available
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Pre-washed Pre-sterilized
Non-sterile available
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Pre-washed Pre-sterilized
Non-sterile available
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Pre-washed Pre-sterilized
Non-sterile and sterile (adaptiQĀ®) available
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Pre-washed Pre-sterilized
Non-sterile and sterile (adaptiQĀ®) available
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Pre-washed Pre-sterilized
Sterile packaging
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Pre-washed Pre-sterilized
Non-sterile and sterile (only TopLine in adaptiQĀ®) available
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Packaging | Packaging | Packaging | Packaging | Packaging | Packaging | Packaging | Packaging | Packaging | Packaging |
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Fogging video EVERICĀ® lyo
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Vial production process