Woman doing visual quality checks on pharmaceutical vials

EVERIC® lyo Pharmaceutical vial designed for fogging prevention during lyophilization

Name: EVERIC® lyo
Brand: SCHOTT Pharma

Overview

Prevent fogging and improve residual emptying

Due to low stability in liquid form, over 50% of biologics are lyophilized. But fogging during freeze-drying can lead to costly rejects. In addition, vials are often overfilled to offset losses from poor residual emptying after reconstitution.

To address these challenges, EVERIC® lyo features a hydrophobic surface. This is achieved through plasma impulse chemical vapor deposition (PICVD), which forms a covalently bonded inner coating that avoids the need for siliconization, which can increase the risk of free silicone. This innovative design prevents fogging during lyophilization and improves residual emptying after reconstitution.

Made of Type I Borosilicate Glass and available in TopLine quality, these pharmaceutical glass vials offer improved lyophilization for injectable drugs thanks to their chemically uniform hydrophobic inner coating.

Ultimately, EVERIC® lyo not only minimizes fogging and improves residual emptying but also enhances patient safety and lyophilization efficiency.

EVERIC® lyo & amber - full protection for sensitive molecules such as antibody-drug conjugates (ADCs)

Combine the functional benefits of EVERIC® lyo with light protection provided by EVERIC® amber, which is made from FIOLAX® amber glass that effectively absorbs light, while ensuring full compliance with USP, Ph. Eur., and JP light transmission standards.

Benefits

A unique combination of hydrophobic behavior and no free silicone

EVERIC® lyo is unique because of its hydrophobic inner surface, formed without the use of silicone. This is particularly beneficial since the risk of free silicone is reduced. Made of high quality Type I FIOLAX® Borosilicate Glass, EVERIC® lyo vials prevent fogging during lyophilization and offer less risk of lyo cake disruption, resulting in fewer cosmetic rejects and reduced production costs.

No fogging

Fog-free lyophilization, thanks to a hydrophobic inner surface

Less cosmetic defects

Elegant lyo cake reduces the amount of cosmetic-related rejects

No overfilling required

Improved emptying results in less residual volume to make overfilling obsolete

No risk of free silicone

Covalently bonded Si-O-C-H coating applied using PICVD technology

Applications

Improved lyophilization process for injectable drugs

EVERIC® lyo vials are designed to prevent fogging and improve residual emptying, ensuring patient safety and dosing accuracy. With vaccines often mass-produced and requiring stable storage for transport, EVERIC® lyo pharmaceutical glass vials support a seamless fill-and-finish process. Their hydrophobic inner coating reduces fogging during freeze-drying, addressing challenges that are typical for sensitive formulations such as antibody-drug conjugates (ADCs), as well as a variety of other drugs.

In addition, its compatibility with EVERIC® amber makes EVERIC® lyo and amber the perfect fit for light-sensitive ADCs, ensuring light transmission compliance with the USP, Ph. Eur. and JP regulatory bodies.

Available in pre-washed, pre-sterilized ready-to-use (RTU) configurations, they are compatible with a wide range of fill-and-finish lines and can remain nested throughout the whole process, including freeze-drying.

Diagram of an EVERIC® lyo vial with close-up of the inner and outer surface

Specifications


Product Name	Product Name EVERIC® lyo	Product Name EVERIC® pure	Product Name EVERIC® care	Product Name EVERIC® freeze	Product Name EVERIC® strong & smooth	Product Name EVERIC® smart	Product Name EVERIC® plus	Product Name adaptiQ®	Product Name Core Vials
Applications	Applications Drugs that need lyophilization	Applications Default solution for biologics, diluents, low-filled and high-value drugs	Applications Drugs in high alkaline pH range	Applications Drugs that need deep-cold storage down to -80°	Applications Improved bulk fill-and-finish	Applications Track and trace solution	Applications Leachable-sensitive drugs in neutral and acidic pH range	Applications Pre-washed and pre-sterilized for leaner fill-and-finish	Applications Default solution for generics, chemicals
Tubing Container Material	Tubing Container Material FIOLAX®	Tubing Container Material FIOLAX® CHR (controlled hydrolytic resistance)	Tubing Container Material FIOLAX® CHR (controlled hydrolytic resistance)	Tubing Container Material FIOLAX® OS (optimized strength)	Tubing Container Material FIOLAX® OS (optimized strength)	Tubing Container Material FIOLAX®	Tubing Container Material FIOLAX®	Tubing Container Material Depending on bulk vial used	Tubing Container Material FIOLAX®
Format	Format 2-50R	Format 2-50R	Format 2R, 6R, 10R	Format 2-30R	Format 2-30R	Format 2-30R	Format 2-50R	Format 2-50R	Format 2-100R
Quality Level	Quality Level TopLine	Quality Level TopLine	Quality Level TopLine	Quality Level TopLine	Quality Level TopLine	Quality Level TopLine	Quality Level TopLine	Quality Level TopLine	Quality Level StandardLine, TopLine, TopLine Packages
Closure Systems	Closure Systems Stopper + seal	Closure Systems Stopper + seal	Closure Systems Stopper + seal	Closure Systems Stopper + seal	Closure Systems Stopper + seal	Closure Systems Stopper + seal	Closure Systems Stopper + seal	Closure Systems Stopper + seal or press-fit cap	Closure Systems Stopper + seal
Pre-washed Pre-sterilized	Pre-washed Pre-sterilized Non-sterile and sterile (adaptiQ®) available	Pre-washed Pre-sterilized Non-sterile and sterile (adaptiQ®) available	Pre-washed Pre-sterilized Non-sterile and sterile (adaptiQ®) available	Pre-washed Pre-sterilized Non-sterile available	Pre-washed Pre-sterilized Non-sterile available	Pre-washed Pre-sterilized Non-sterile and sterile (adaptiQ®) available	Pre-washed Pre-sterilized Non-sterile and sterile (adaptiQ®) available	Pre-washed Pre-sterilized Sterile packaging	Pre-washed Pre-sterilized Non-sterile and sterile (only TopLine in adaptiQ®) available
Packaging	Packaging Bulk tray, adaptiQ® solution (tray, cup nest) DATASHEET	Packaging Bulk tray, adaptiQ® solution (tray, cup nest) DATASHEET	Packaging Bulk tray, adaptiQ® solution (tray, cup nest) DATASHEET	Packaging Bulk tray DATASHEET	Packaging Bulk tray DATASHEET	Packaging Bulk tray, adaptiQ® solution (tray, cup nest) DATASHEET	Packaging Bulk tray, adaptiQ® solution (tray, cup nest) DATASHEET	Packaging Pre-sterilized vials tray or cup nest CUP TRAY	Packaging Bulk tray, adaptiQ® solution (tray, cup nest) STANDARDLINE TOPLINE

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Fogging video EVERIC® lyo

Fogging video EVERIC® lyo
Vial production process

How to overcome lyophilization challenges

Discover how EVERIC® lyo vials tackle key challenges in lyophilization, from preventing fogging to improving residual emptying. Learn how their hydrophobic inner coating and silicone-free design enhance patient safety, dosing accuracy, and vaccine storage efficiency. Download our whitepaper to learn more.

How to store highly sensitive drugs - Next.PNG

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