Prevent fogging and improve residual emptying
Due to the low stability of biologics, more than 50% are lyophilized. However, lyophilization can cause fogging, which results in an increase in rejects, while vials are often overfilled to compensate for losses due to poor residual emptying after reconstitution. A solution to both issues is the unique SCHOTT TopLyo® vial, which combines hydrophobic behavior and the avoidance of free silicone to prevent fogging and improve residual emptying.
Improved lyophilization for injectable drugs
A unique combination of hydrophobic behavior and no free silicone
SCHOTT TopLyo® vials feature a chemically uniform hydrophobic coating that leads to less fogging during the lyophilization process, as well as lower disruption of the lyo cake. This results in less cosmetic rejects and reduced production costs.
The application of the coating via PICVD (plasma impulse chemical vapor deposition) forms a covalent bond, avoiding free silicone. SCHOTT TopLyo® is therefore unique in combining hydrophobic behavior and the avoidance of free silicone to avoid fogging and improve residual emptying.
Increased lyo process efficiency and patient safety
Made using high quality Type I FIOLAX® Borosilicate Glass.
Formats range from 2-50 R.
Packaging options include bulk tray, as well as pre-washed and pre-sterilized adaptiQ® (tray, cup nest, clip nest)*.
TopLine quality level with an additional, dedicated, statistical in-production release test.
*50 R not available in clip nest configuration.
Ready-to-use TopLyo® vials
Small batches of personalized medications and high-value pharmaceuticals often present challenges for fill-and-finish operations. Not only do they require higher quality containers, but they also require more flexibility, with frequent switching between different medications to avoid costly waste.
SCHOTT TopLyo® vials are available in a pre-washed and pre-sterilized ready-to-use (RTU) configuration, and can be processed on a variety of new and existing fill-and-finish lines, keeping vials nested throughout the process (including freeze-drying).