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EVERIC® vials

A modular vial concept tailored to your individual needs
Problem statement

A modular vial concept for rising drug requirements

Modern medicine is essential to health and life. Through constant research and development, drugs have become more and more personalized, with their complex structures demanding increasingly special requirements. We help to keep them reliable, safe, and effective as they reach people to maintain or improve their health.

SCHOTT Pharma's EVERIC® vials present an innovative modular container concept for the pharmaceutical industry, seamlessly connecting manufacturers and users through a range of integrated benefits. Each module is crafted from FIOLAX® Type I Borosilicate Glass, renowned for its exceptional properties.

Challenges

Different needs require flexible solutions

Pharmaceutical companies face significant challenges in choosing the appropriate vial for their medicines as they become more complex and have more specific requirements. The vial’s inner surface is crucial for keeping drug-container interaction to a minimum and maintaining the medication’s efficacy. Features such as precise geometry and an improved outer surface can further optimize the fill-and-finish process.

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    Sensitive injectables such as biologics

    Conventional vials can encounter increased leachable levels caused by a change in the inner surface of the near-bottom region of the vial during hot-forming. This is particularly relevant for low-filled vials, which are used to store high-value biologics. Glass leachables can cause stability issues for complex and sensitive molecules, leading to pH-shift, protein aggregation, or denaturation. This is even more challenging for drugs buffered in high pH solutions. In addition, conventional vials have a higher risk of glass delamination, which can pose a huge threat to patient safety. The vial’s inner surface can also influence the adsorption of proteins, which can cause issues for drug concentration.
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    Deep-cold therapies

    The rise of mRNA vaccines introduced new therapies that need to be stored at deep-cold temperatures. Combined with the potential of multiple freeze-thaw cycles, the stress on the glass can increases the chances of vial breakage, especially if the containers are pre-flawed. The risk of breakage is of paramount concern to pharmaceutical companies given the significant value of the drugs.
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    Fill-and-finish processing

    During conventional bulk fill-and-finish processing, vials are constantly subjected to glass-to-glass contact and load. This can result in an increase in cosmetic defects, a higher risk of breakage, and the potential for sticking and climbing during depyrogenation. The consequences of this are reduced line speed, higher final rejects, and increased downtimes and interruptions, resulting in elevated costs.
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    Unique traceability

    Traceability for individual containers has a huge potential that’s yet to be exploited by the pharmaceutical industry. Targeted recalls, a reduced risk of mix-ups, optimization during fill-and-finish, and optimization of freeze-drying processes are just a few areas where a unique code can help to reduce costs and increase safety.
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    Modularity

    Create the vial tailored to your individual challenges

    It’s not uncommon to face multiple challenges when selecting the appropriate vial. During the drug development stage, the primary focus is on drug stability, with a particular emphasis on the vial's inner surface. However, in later stages, the container's stability and strength become a crucial factor to consider. Looking further ahead, manufacturing aspects become critical, including achievable line speed and reject rates during fill-and-finish. EVERIC® was specifically designed to address these challenges, and the properties of various EVERIC® vials can be combined to solve multiple issues simultaneously.

    Discover the EVERIC® modularity in the visualization below.


    EVERIC® modularity configurator

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    Not available due to previous selections

    • EVERIC® pure

      Your first-choice Type I Borosilicate Glass vial – low leachables, minimized pH shift, delamination under full control

    • EVERIC® plus

      Guardian of your acidic drug – protect your leachable-sensitive drug in low to medium pH

    • EVERIC® lyo

      Your secret weapon for lyophilization – its hydrophobic inner coating prevents fogging and minimized residual volume

    • EVERIC® care

      Your all-rounder – protect your leachable sensitive high-pH drug and benefit from a hydrophobic inner surface to improve residual emptying

    • Choose No Option

    • EVERIC® strong

      Optimized strength within ISO to reduce the risk of breakage

    • EVERIC® freeze

      Reduce the risk of breakage - Optimized strength for deep cold storage down to – 80 °C & lyophilization

    • Choose No Option

    • EVERIC® smooth

      Improve your filling line performance – an outer coating that reduces breakage risk and protects from cosmetic defects, decreasing the final reject rate

    • Choose No Option

    • EVERIC® smart

      Tracking from cradle to gate – a data matrix that supports to optimize fill-and-finish, to avoid mix-ups and enables targeted recalls

    • Choose No Option

    Available packaging for your vial

    Not available due to previous selections

    Streamline your fill-and-finish with adaptiQ®, your chosen vial in a pre-washed and pre-sterilized ready-to-use (RTU) configuration. Alternatively, opt for the traditional choice with your chosen vial in a bulk configuration.

    Based on your previous selections, your vial is only available in a traditional bulk configuration and not in adaptiQ® – a pre-washed and pre-sterilized ready-to-use (RTU) packaging system designed to streamline fill-and-finish operations and ensure consistent quality.

    • Sterile (adaptiQ®)

      Streamline your fill-and-finish with adaptiQ® - your chosen vial in a pre-washed and pre-sterilized ready-to-use (RTU) configuration

    • Non-sterile

      The traditional choice – your chosen vial in a bulk configuration
    The solution

    There is no “unsolvable” with EVERIC® vials

    Consisting of six modules, SCHOTT Pharma EVERIC® vials provide a solution for each of these challenges:

    • EVERIC® pure, EVERIC® plus and EVERIC® care offer dedicated inner surfaces to minimize drug-container interaction. EVERIC® lyo provides a hydrophobic inner surface to improve lyophilization.
    • EVERIC® strong and EVERIC® freeze feature optimized geometries and handling to maximize vial strength for a dedicated application.
    • EVERIC® smooth has a coating on its outer surface to increase line speed and reduce cosmetic defects during fill-and-finish.
    • EVERIC® smart enables traceability throughout the complete supply chain via a unique identification.
    Advantages

    EVERIC® vials – your holistic solution

    SCHOTT Pharma’s EVERIC® vials provide tailor-made solutions for all requirements so that medication can securely be stored, transported, and administered to fully benefit the patient. EVERIC® vials deliver medical progress to people, and our goal is to always provide the best possible individual care. Advantages at a glance:

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    Suitable for a broad variety of drug formulations to minimize drug-container interaction.

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    Increases strength for your applications, e.g. deep-cold therapies.

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    Prevents sticking and climbing to optimize your fill-and-finish process and to improve your line performance.

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    Utilizes innovative laser technology to apply a data matrix code, enabling seamless tracking and tracing of your vials.

    Related products

    Comprehensive solutions for every pharmaceutical need

    SCHOTT Pharma offers an extensive portfolio of high-quality products and services designed to meet the diverse needs of the pharmaceutical industry. Explore our innovative solutions and discover how we can support your specific requirements with precision and expertise.

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      Transparent EVERIC® care vial with close up of glass structure

      EVERIC® care | SCHOTT Pharma

      EVERIC® care pharmaceutical glass vials feature a hydrophobic coating that protects sensitive drugs from leachables in the alkaline pH range

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      EVERIC® freeze glass pharmaceutical vial with chemical composition of glass wall

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      SCHOTT Pharma's EVERIC® freeze vials are designed for stability in deep-cold storage, reducing breakage and optimizing pharmaceutical freeze-drying.

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      Transparent glass vial with close up of surface structure

      EVERIC® strong & smooth | SCHOTT Pharma

      SCHOTT Pharma’s break-resistant vial offers increased speed for bulk fill-and-finish lines plus a reduced risk of breakage and lower reject rates

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      Contact form

      Get in touch

      Diana Löber

      Diana Löber

      Global Product Manager Specialty Vials & adaptiQ®

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