Pharmind: Optimizing the Inner Surface of Primary Packaging

The whitepaper titled "Optimizing the Inner Surface of Primary Packaging: Siliconization versus PICVD" explores advancements in the chemical inertness of parenteral packaging glass containers. The study compares uncoated glass, baked-on silicone-coated glass, and glass with an inorganic SiO2 coating applied via Plasma Impulse Chemical Vapor Deposition (PICVD). Key findings highlight that SiO2 coatings provide superior hermetic surface protection, significantly reducing ion leaching and maintaining pH stability, which is crucial for highly sensitive biologics. In contrast, baked-on silicone coatings enhance mechanical properties but do not offer sufficient chemical protection, leading to potential interaction risks with the drug product. The paper underscores the importance of advanced surface treatments to ensure the stability and efficacy of pharmaceuticals over their shelf life.

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